High-mobility group box protein 1 (HMGB1): an alarmin mediating the pathogenesis of rheumatic disease
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منابع مشابه
High-mobility group box protein 1 (HMGB1): an alarmin mediating the pathogenesis of rheumatic disease
High-mobility group box protein 1 (HMGB1) is a non-histone nuclear protein that has a dual function. Inside the cell, HMGB1 binds DNA, regulating transcription and determining chromosomal architecture. Outside the cell, HMGB1 can serve as an alarmin to activate the innate system and mediate a wide range of physiological and pathological responses. To function as an alarmin, HMGB1 translocates f...
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ژورنال
عنوان ژورنال: Arthritis Research & Therapy
سال: 2008
ISSN: 1478-6354
DOI: 10.1186/ar2440